Non-Hfe Iron Overload: Is Phlebotomy the Answer?
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چکیده
منابع مشابه
Non-hfe Iron Overload: Is Phlebotomy the Answer?
Iron is an essential factor for life, however a physiologically optimal balance is critical. In this article we explore the role of iron as a co-factor in a range of chronic liver diseases and how it may contribute to the development of liver injury, fibrosis, cirrhosis and ultimately hepatocellular carcinoma. Whilst iron depletion therapy through phlebotomy is the most effective method of redu...
متن کاملIron-overload-related disease in HFE hereditary hemochromatosis.
BACKGROUND Most persons who are homozygous for C282Y, the HFE allele most commonly asssociated with hereditary hemochromatosis, have elevated levels of serum ferritin and transferrin saturation. Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial. METHODS We assessed HFE mutations in 31,192 persons of northern European descent betwe...
متن کاملHFE Gene Mutations, Iron Overload and Cryptogenic Liver Cirrhosis
The diagnosis of cryptogenic cirrhosis is an exclusion diagnosis. It has become far less frequent over the last decades , but it still effects a significant number of patients. Many previously unknown chronic liver disease entities were described in the second half of the last century, including chronic viral hepatitis B, C and D, along with refined criteria for diagnosing autoimmune hepatitis ...
متن کاملIron-Overload–Related Disease in HFE Hereditary Hemochromatosis
Katrina J. Allen, M.D., Ph.D., Lyle C. Gurrin, Ph.D., Clare C. Constantine, Ph.D., Nicholas J. Osborne, Ph.D., Martin B. Delatycki, M.D., Ph.D., Amanda J. Nicoll, M.D., Ph.D., Christine E. McLaren, Ph.D., Melanie Bahlo, Ph.D., Amy E. Nisselle, B.Sc., Chris D. Vulpe, M.D., Ph.D., Gregory J. Anderson, Ph.D., Melissa C. Southey, Ph.D., Graham G. Giles, Ph.D., Dallas R. English, Ph.D., John L. Hopp...
متن کاملKey words HFE mutation, HCV infection, iron overload Correspondence
Indeed, when the iron content of liver biopsies from HCV-infected patients was measured, there was only a real increase in hepatic iron in 10% of the cases, despite a rise in serum ferritin and transferrin saturation.8 It should be pointed out that cytolysis could have led to the increase in both serum ferritin and transferrin saturation. In conclusion, it is unlikely that the C282Y mutation of...
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ژورنال
عنوان ژورنال: Current Hepatitis Reports
سال: 2012
ISSN: 1540-3416,2195-9595
DOI: 10.1007/s11901-012-0153-3